Qualifying an annotation with the qualifier NOT allows annotators to state that a particular gene product is not associated with a particular GO term. “our favorite protein is not found in the nucleus”). NOT is also used when a cited reference explicitly says (e.g. For example, if a protein has sequence similarity to an enzyme (whose activity is GO:nnnnnnn), but has been shown experimentally not to have the enzymatic activity, it is annotated as NOT GO:nnnnnnn. This is particularly important in cases where associating a GO term with a gene product should be avoided (but might otherwise be made, especially by an automated method). loss of an active site or rapid divergence after a duplication event) over the course of evolution. NOT is used to make an explicit note that a gene product has been experimentally demonstrated not to be able to carry out a particular activity or it has been shown to have had a loss of function (e.g. The NOT, contributes_to, and colocalizes_with qualifiers are used in the GAF format. Some annotations are modified by qualifiers, which have specific usage rules and meanings within GO.
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